Synthesis of 3-Substituted Pyrrolidines via Palladium-Catalyzed Hydroarylation

Sweeney, J.B. and Doulcet, J. and Thapa, B. (2018) Synthesis of 3-Substituted Pyrrolidines via Palladium-Catalyzed Hydroarylation. iScience, 9. pp. 328-336. ISSN 2589-0042

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Abstract

Metal-catalyzed reactions have revolutionized synthetic chemistry, allowing access to unprecedented molecular architectures with powerful properties and activities. Nonetheless, some transformations remain sparse in number, or out of reach, even with the diverse modern catalytic chemical arsenal, including bimolecular alkene hydroarylation reactions. We report here a broad-scope, palladium-catalyzed pyrroline hydroarylation process that gives 3-aryl pyrrolidines, a class of small molecules with potency in a diverse range of biological scenarios. Thus, whereas N-acyl pyrrolines usually undergo palladium-catalyzed arylation to give alkene products, the corresponding reactions of N-alkyl pyrrolines deliver products of hydroarylation, pyrrolidines. The process has broad substrate scope and can be used to directly deliver drug-like molecules in a single step from readily available precursors. Chemistry; Catalysis; Organic Synthesis © 2018 The Authors

Item Type:
Journal Article
Journal or Publication Title:
iScience
Subjects:
ID Code:
134722
Deposited By:
Deposited On:
22 Jun 2019 09:18
Refereed?:
Yes
Published?:
Published
Last Modified:
19 Aug 2020 05:30