Effect of charge fluctuations on the permeation of ions through biological ion channels

Tindjong, R. and Luchinsky, D. G. and McClintock, P. V.E. and Kaufman, I. and Eisenberg, R. S. (2007) Effect of charge fluctuations on the permeation of ions through biological ion channels. In: Noise and Fluctuations - 19th International Conference on Noise and Fluctuations, ICNF 2007 :. AIP Conference Proceedings . American Institute of Physics, JPN, pp. 647-650. ISBN 9780735404328

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Abstract

The effect of charge fluctuations at the mouth of an open ion channel on its conduction mechanism is analyzed within the framework of self-consistent Brownian dynamics simulations. It is shown that volume charge fluctuations at the channel mouth can be modelled as a generalized shot noise and result in strong modulation of the potential barrier for an ion at the selectivity site, on a sub-nanosecond time scale.

Item Type:
Contribution in Book/Report/Proceedings
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3100/3100
Subjects:
?? charge fluctuationion channelslangevin equationpoisson equationself-consistent approachgeneral physics and astronomy ??
ID Code:
134261
Deposited By:
Deposited On:
22 Jun 2019 01:00
Refereed?:
Yes
Published?:
Published
Last Modified:
16 Jul 2024 04:35