N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder

Moreno-Villanueva, M. and Morath, J. and Vanhooren, V. and Elbert, T. and Kolassa, S. and Libert, C. and Bürkle, A. and Kolassa, I.-T. (2013) N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder. Translational Psychiatry, 3. ISSN 2158-3188

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Abstract

The prevalence of age-related diseases is increased in individuals with post-traumatic stress disorder (PTSD). However, the underlying biological mechanisms are still unclear. N-glycosylation is an age-dependent process, identified as a biomarker for physiological aging (GlycoAge Test). To investigate whether traumatic stress accelerates the aging process, we analyzed the N-glycosylation profile in n=13 individuals with PTSD, n=9 trauma-exposed individuals and in n=10 low-stress control subjects. Individuals with PTSD and trauma-exposed individuals presented an upward shift in the GlycoAge Test, equivalent to an advancement of the aging process by 15 additional years. Trauma-exposed individuals presented an intermediate N-glycosylation profile positioned between severely traumatized individuals with PTSD and low-stress control subjects. In conclusion, our data suggest that cumulative exposure to traumatic stressors accelerates the process of physiological aging.

Item Type:
Journal Article
Journal or Publication Title:
Translational Psychiatry
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2800/2803
Subjects:
ID Code:
134018
Deposited By:
Deposited On:
22 Jun 2019 09:14
Refereed?:
Yes
Published?:
Published
Last Modified:
19 Aug 2020 05:27