Development of Leishmania mexicana in Lutzomyia longipalpis in the absence of sugar feeding

da Costa, Samara G and Moraes, Caroline da Silva and Bates, Paul and Dillon, Rod and Genta, Fernando Ariel (2019) Development of Leishmania mexicana in Lutzomyia longipalpis in the absence of sugar feeding. Memorias do Instituto Oswaldo Cruz, 114. ISSN 0074-0276

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Abstract

The leishmaniases are caused by Leishmania parasites and transmitted through the bites of phlebotomine sand flies. During parasite development inside the vector's midgut, promastigotes move towards the stomodeal valve, a mechanism that is crucial for transmission. It has been reported that the sugar meal acquired by sand flies during feeding between bloodmeals is essential for the development and migration of parasites. We demonstrated that the distribution of Leishmania mexicana parasites was affected by the sugar meals obtained by the sand flies. Promastigote migration towards the cardia region seems to be only partially based on the stimuli provided by sugar molecules. In the absence of sugars, significant amounts of parasites developed in the hindgut. In addition, sugar meals were important for the survival of sand flies, especially during blood digestion, presumably supporting their energy requirements.

Item Type: Journal Article
Journal or Publication Title: Memorias do Instituto Oswaldo Cruz
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/2700/2726
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 133985
Deposited By: ep_importer_pure
Deposited On: 29 May 2019 08:55
Refereed?: Yes
Published?: Published
Last Modified: 20 Sep 2019 02:10
URI: https://eprints.lancs.ac.uk/id/eprint/133985

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