Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography

Zhang, Zijian and Williams, Bryan M. and Zheng, Yalin and Lin, Hungyen and Shen, Yaochun (2019) Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography. Coatings, 9 (5). ISSN 2079-6412

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Abstract

Optical coherence tomography (OCT) has recently been demonstrated as a powerful tool to image through pharmaceutical film coatings. Majority of the existing systems can, however, resolve film coatings for thickness greater than 10 µm. Here we report on an ultra-high-resolution (UHR) OCT system, with 1 µm axial and 1.6 µm lateral resolutions, which can resolve thin coatings at approximately 4 µm. We further demonstrate a novel application of the system for differentiating generic and branded suppliers of paracetamol tablets.

Item Type:
Journal Article
Journal or Publication Title:
Coatings
Subjects:
ID Code:
133978
Deposited By:
Deposited On:
29 May 2019 10:40
Refereed?:
Yes
Published?:
Published
Last Modified:
30 Sep 2020 08:55