Oxadiazole isomers:All bioisosteres are not created equal

Goldberg, Kristin and Groombridge, Sam and Hudson, Julian and Leach, Andrew G. and MacFaul, Philip A. and Pickup, Adrian and Poultney, Ruth and Scott, James S. and Svensson, Per H. and Sweeney, Joseph (2012) Oxadiazole isomers:All bioisosteres are not created equal. MedChemComm, 3 (5). pp. 600-604. ISSN 2040-2503

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Abstract

Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.

Item Type:
Journal Article
Journal or Publication Title:
MedChemComm
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3000/3003
Subjects:
ID Code:
133278
Deposited By:
Deposited On:
30 Apr 2019 11:30
Refereed?:
Yes
Published?:
Published
Last Modified:
01 Sep 2020 05:48