Murray, Paul M. and Bower, John F. and Cox, David K. and Galbraith, Ewan K. and Parker, Jeremy S. and Sweeney, Joseph B. (2013) A robust first-pass protocol for the Heck-Mizoroki reaction. Organic Process Research and Development, 17 (3). pp. 397-405. ISSN 1083-6160
Full text not available from this repository.Abstract
The Heck-Mizoroki (HM) reaction is one of the most widely used C-C bond-forming methods of contemporary synthesis. Notwithstanding this, these reactions frequently require significant optimization before efficient transformations can be obtained. We describe here the results of a study that aimed to establish a generic experimental protocol for HM reactions which enables acceptable yields from first-pass experiments. The methodology utilizes readily available stable catalysts and can be applied to a broad range of coupling partners.