A robust first-pass protocol for the Heck-Mizoroki reaction

Murray, Paul M. and Bower, John F. and Cox, David K. and Galbraith, Ewan K. and Parker, Jeremy S. and Sweeney, Joseph B. (2013) A robust first-pass protocol for the Heck-Mizoroki reaction. Organic Process Research and Development, 17 (3). pp. 397-405. ISSN 1083-6160

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The Heck-Mizoroki (HM) reaction is one of the most widely used C-C bond-forming methods of contemporary synthesis. Notwithstanding this, these reactions frequently require significant optimization before efficient transformations can be obtained. We describe here the results of a study that aimed to establish a generic experimental protocol for HM reactions which enables acceptable yields from first-pass experiments. The methodology utilizes readily available stable catalysts and can be applied to a broad range of coupling partners.

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Journal Article
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Organic Process Research and Development
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30 Apr 2019 11:30
Last Modified:
22 Nov 2022 07:29