Chronic Antipsychotic Treatment Modulates Aromatase (CYP19A1) Expression in the Male Rat Brain

Bogus, Katarzyna and Pałasz, Artur and Suszka-Świtek, Aleksandra and Worthington, John Joseph and Krzystanek, Marek and Wiaderkiewicz, Ryszard (2019) Chronic Antipsychotic Treatment Modulates Aromatase (CYP19A1) Expression in the Male Rat Brain. Journal of Molecular Neuroscience, 68 (2). pp. 311-317. ISSN 0895-8696

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Abstract

Antipsychotic drugs, known as the antagonists of dopaminergic receptors, may also affect a large spectrum of other molecular signaling pathways in the brain. Despite the numerous ongoing studies on neurosteroid action and regulation, there are no reports regarding the influence of extended treatment with typical and atypical neuroleptics on brain aromatase (CYP19A1) expression. In the present study, we assessed for the first time aromatase mRNA and protein levels in the brain of rats chronically (28 days) treated with olanzapine, clozapine, and haloperidol using quantitative real-time PCR, end-point RT-PCR, and Western blotting. Both clozapine and haloperidol, but not olanzapine treatment, led to an increase of aromatase mRNA expression in the rat brain. On the other hand, aromatase protein level remained unchanged after drug administration. These results cast a new light on the pharmacology of examined antipsychotics and contribute to a better understanding of the mechanisms responsible for their action. The present report also underlines the complex nature of potential interactions between neuroleptic pharmacological effects and physiology of brain neurosteroid pathways.

Item Type: Journal Article
Journal or Publication Title: Journal of Molecular Neuroscience
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/2800/2804
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 133166
Deposited By: ep_importer_pure
Deposited On: 24 Apr 2019 15:25
Refereed?: Yes
Published?: Published
Last Modified: 10 Sep 2019 00:18
URI: https://eprints.lancs.ac.uk/id/eprint/133166

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