Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration

Antonica, Francesco and Orietti, Lorenzo Carlo and Mort, Richard Lester and Zernicka-Goetz, Magdalena (2019) Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration. Developmental Biology, 450 (2). pp. 132-140. ISSN 0012-1606

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Abstract

Migration of Anterior Visceral Endoderm (AVE) is a critical symmetry breaking event in the early post-implantation embryo development and is essential for establishing the correct body plan. Despite much effort, cellular and molecular events influencing AVE migration are only partially understood. Here, using time-lapse live imaging of mouse embryos, we demonstrate that cell division in the embryonic visceral endoderm is coordinated with AVE migration. Moreover, we demonstrate that temporal inhibition of FGF signalling during the pre-implantation specification of embryonic visceral endoderm perturbs cell cycle progression, thus affecting AVE migration. These findings demonstrate that coordinated cell cycle progression during the implantation stages of development is important for post-implantation morphogenesis in the mouse embryo.

Item Type: Journal Article
Journal or Publication Title: Developmental Biology
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1300/1312
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 133109
Deposited By: ep_importer_pure
Deposited On: 22 Jun 2019 09:09
Refereed?: Yes
Published?: Published
Last Modified: 17 Sep 2019 00:10
URI: https://eprints.lancs.ac.uk/id/eprint/133109

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