Raman spectroscopy can detect and monitor cancer at cellular level:Analysis of resistant and sensitive subtypes of testicular cancer cell lines

Movasaghi, Z. and Rehman, S. and Rehman, I.U. (2012) Raman spectroscopy can detect and monitor cancer at cellular level:Analysis of resistant and sensitive subtypes of testicular cancer cell lines. APPLIED SPECTROSCOPY REVIEWS, 47 (7). pp. 571-581. ISSN 0570-4928

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Abstract

Raman spectroscopy has been applied to analyze testicular cancer cell lines. Spectral differences between resistant and sensitive subtypes of testicular cancer cell line 833k samples were successfully analysed. The technique allowed reproducible and quantitative analysis of the specimen and illustrated the chemical specifications of the samples precisely. Six pairs of testicular cancer cell line 833k were studied and the findings were backed by statistical methods; that is, partial least squares discriminant analysis (PLS-DA). It was concluded that Raman spectroscopy can objectively differentiate between resistant and sensitive cell lines. These results suggest that in the future it may be possible to use cell lines and diagnostic Raman spectroscopy for preoperative classification of biological molecules. Further research is underway to determine whether results obtained from spectroscopic analysis of cell lines can be applied to actual human tissue samples. Copyright © Taylor & Francis Group, LLC.

Item Type:
Journal Article
Journal or Publication Title:
APPLIED SPECTROSCOPY REVIEWS
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1600/1607
Subjects:
ID Code:
132942
Deposited By:
Deposited On:
16 Apr 2019 15:55
Refereed?:
Yes
Published?:
Published
Last Modified:
01 Jan 2020 11:57