Synthesis and in-vitro cytotoxicity analysis of microwave irradiated nano-apatites

Nazir, R. and Samad Khan, A. and Ahmed, A. and Ur-Rehman, A. and Anwar Chaudhry, A. and Ur Rehman, I. and Wong, F.S.L. (2013) Synthesis and in-vitro cytotoxicity analysis of microwave irradiated nano-apatites. Ceramics International, 39 (4). pp. 4339-4347. ISSN 0272-8842

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Nano-sized calcium deficient apatite (CDA) micelles were synthesized through microwave assisted the wet precipitation technique. Cetyltrimethylammonium bromide (CTAB) was employed as surface template to furnish the CDA particles with tailored size and shape. As-precipitated CDA was heat treated to observe the effect of heat treatment temperature on the interatomic rearrangement of entities within the apatite lattice. This transformation is responsible for conversion of CDA to β-tricalcium phosphate (β-TCP) at specific temperature. The phase purity, particles size, morphology and transformation kinetics were analyzed using X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and Thermogravimetric Analysis (TGA). In-vitro studies were performed on β-TCP with three cell lines: osteoblasts, HeLa, and SF 767. The results showed that nano-sized particles were successfully synthesized in short time. The cells had appreciable proliferation/attachment on the surface of these nano-particles. It is concluded that the microwave irradiated synthesized β-TCP has good capacity in terms of biocompatibility and has the potential to be used in hard tissue regeneration applications. © 2012 Elsevier Ltd and Techna Group S.r.l.

Item Type:
Journal Article
Journal or Publication Title:
Ceramics International
Uncontrolled Keywords:
?? cytotoxicitymicrowave assisted synthesisnano-particlestricalcium phosphate (tcp)calcium deficient apatitescell linescetyltrimethylammonium bromideeffect of heat treatmentsin-vitromicrowave assistednano-apatitesnano-sized particlesparticles sizesphase puri ??
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17 Apr 2019 09:05
Last Modified:
15 Jul 2024 19:18