Preparation and characterization of multiactive electrospun fibers:Poly-ε-carpolactone fibers loaded with hydroxyapatite and selected NSAIDs

Karavasili, C. and Bouropoulos, N. and Kontopoulou, I. and Smith, A. and Van Der Merwe, S.M. and Rehman, I.U.R. and Ahmad, Z. and Fatouros, D.G. (2014) Preparation and characterization of multiactive electrospun fibers:Poly-ε-carpolactone fibers loaded with hydroxyapatite and selected NSAIDs. Journal of Biomedical Materials Research Part A, 102 (8). pp. 2583-2589. ISSN 1549-3296

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Abstract

Electrospun poly-ε-caprolactone fibers were employed as hosts for hydroxypatite and nonsteroidal anti-inflammatory drugs (NSAIDs) ibuprofen (IBU) and indomethacin (INDO) (separately). The fibers (size range between 400 and 20 μm) were characterized by means of X-ray diffraction, differential scanning calorimetry, fourier-transform infrared spectroscopy and scanning electron microscopy. The physicochemical characterization of the fibers indicated that the drugs are associated with the fibers in an amorphous state. The release of IBU and INDO was monitored in PBS pH 7.4. A rapid release was observed for both drugs. Finally, bioactivity studies in simulated body fluid revealed the formation of hydroxyapatite, indicating that the fibers could be further utilized as materials for coupled (or multipurpose) biomedical and biomaterial engineering applications. © 2013 Wiley Periodicals, Inc.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Biomedical Materials Research Part A
Subjects:
ID Code:
132931
Deposited By:
Deposited On:
17 Apr 2019 09:30
Refereed?:
Yes
Published?:
Published
Last Modified:
24 Mar 2020 08:34