Evaluation of in vitro bioactivity and biocompatibility of Bioglass®-reinforced polyethylene composite

Huang, J. and Di Silvio, L. and Wang, M. and Rehman, I. and Ohtsuki, C. and Bonfield, W. (1997) Evaluation of in vitro bioactivity and biocompatibility of Bioglass®-reinforced polyethylene composite. Journal of Materials Science: Materials in Medicine, 8 (12). pp. 809-813. ISSN 0957-4530

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Abstract

The bioactivity and biocompatibility of Bioglass®-reinforced high-density polyethylene composite (Bioglass®/HDPE) have been evaluated in simulated body fluid (SBF) and by in vitro cell culture, respectively. The formation of a biologically active hydroxy-carbonate apatite (HCA) layer on the composite surface after immersion in SBF was demonstrated by thin-film X-ray diffraction, infrared spectroscopy and scanning electron microscopy, indicating the in vitro bioactivity of Bioglass®/HDPE composites. The HCA layer was formed on the 40 vol% composite surface within 3 days immersion in SBF at a formation rate comparable to those on bioactive glass-ceramics, showing that in vitro bioactivity could be obtained in a composite. Furthermore, the composite was biocompatible to primary human osteoblast-like cells. In comparison with unfilled HDPE and tissue culture plastic control, a significant increase in cellular metabolic activity was found on the composite. Therefore, Bioglass®/HDPE composites have a promising biological response as a potential implant material. The bioactivity and biocompatibility of Bioglass-reinforced high-density polyethylene composite (Bioglass/HDPE) have been evaluated in simulated body fluid (SBF) and by in vitro cell culture, respectively. The formation of a biologically active hydroxy-carbonate apatite (HCA) layer on the composite surface after immersion in SBF was demonstrated by thin-film X-ray diffraction, infrared spectroscopy and scanning electron microscopy, indicating the in vitro bioactivity of Bioglass/HDPE composites. The HCA layer was formed on the 40 vol% composite surface within 3 days immersion in SBF at a formation rate comparable to those on bioactive glass-ceramics, showing that in vitro bioactivity could be obtained in a composite. Furthermore, the composite was biocompatible to primary human osteoblast-like cells. In comparison with unfilled HDPE and tissue culture plastic control, a significant increase in cellular metabolic activity was found on the composite. Therefore, Bioglass/HDPE composites have a promising biological response as a potential implant material.

Item Type: Journal Article
Journal or Publication Title: Journal of Materials Science: Materials in Medicine
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1300/1304
Subjects:
Departments: Faculty of Science and Technology > Engineering
ID Code: 132883
Deposited By: ep_importer_pure
Deposited On: 16 Apr 2019 13:30
Refereed?: Yes
Published?: Published
Last Modified: 05 Nov 2019 05:40
URI: https://eprints.lancs.ac.uk/id/eprint/132883

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