Preparation and characterisation of controlled porosity alginate hydrogels made via a simultaneous micelle templating and internal gelation process

Partap, S. and Muthutantri, A. and Rehman, I.U. and Davis, G.R. and Darr, J.A. (2007) Preparation and characterisation of controlled porosity alginate hydrogels made via a simultaneous micelle templating and internal gelation process. Journal of Materials Science, 42 (10). pp. 3502-3507. ISSN 0022-2461

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Abstract

Controlled porosity alginate hydrogel monoliths were synthesised by simultaneous micelle templating (MT) and an internal gelation reaction. In water, the self assembling surfactant, cetyltrimethylammonium bromide (CTAB) formed non-spherical micelles that were used as a template for pore formation. The porous microstructure was assessed by mercury intrusion porosimetry (MIP), helium pycnometry, X-ray microtomography (XMT) and scanning electron microscopy (SEM), respectively. The MT hydrogels displayed relatively monodisperse pore size distributions (with pore sizes ranging from 32.5 μm to 164.0 μm), high total pore volumes (4.5-20.3 cm3/g) and high degrees of porosity (83-97%). Some control over pore size distributions was achieved by varying the surfactant concentration; higher surfactant concentrations, led to smaller pores with lower total pore volumes. Uniaxial compression testing revealed that hydrogels made via MT are stable in cell culture media for 28 days. Fourier transform infrared (FTIR) spectroscopy data, suggested that all surfactant could be removed from the final product by washing with ethanol and water, making these hydrogels potentially suitable for tissue engineering (TE) applications. © Springer Science+Business Media, LLC 2007.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Materials Science
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2200/2210
Subjects:
ID Code:
132865
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Deposited On:
16 Apr 2019 14:55
Refereed?:
Yes
Published?:
Published
Last Modified:
09 Sep 2020 05:55