A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence

Roberts, Ryan and Yee, Pinn Tsin Isabel and Mujawar, Shama and Lahiri, Chandrajit and Poh, Chit Laa and Gatherer, Derek (2019) A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence. Scientific Reports, 9 (1). ISSN 2045-2322

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Abstract

Enterovirus A71 (EV-A71) is an emerging pathogen in the Enterovirus A species group. EV-A71 causes hand, foot and mouth disease (HFMD), with virulent variants exhibiting polio-like acute flaccid paralysis and other central nervous system manifestations. We analysed all enterovirus A71 complete genomes with collection dates from 2008 to mid-2018. All sub-genotypes exhibit a strong molecular clock with omega (dN/dS) suggesting strong purifying selection. In sub-genotypes B5 and C4, positive selection can be detected at two surface sites on the VP1 protein, also detected in positive selection studies performed prior to 2008. Toggling of a limited repertoire of amino acids at these positively selected residues over the last decade suggests that EV-A71 may be undergoing a sustained frequency-dependent selection process for immune evasion, raising issues for vaccine development. These same sites have also been previously implicated in virus-host binding and strain-associated severity of HFMD, suggesting that immune evasion may be an indirect driver for virulence (154 words).

Item Type: Journal Article
Journal or Publication Title: Scientific Reports
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1000
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 132849
Deposited By: ep_importer_pure
Deposited On: 18 Apr 2019 13:50
Refereed?: Yes
Published?: Published
Last Modified: 13 Sep 2019 03:07
URI: https://eprints.lancs.ac.uk/id/eprint/132849

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