A study of the effect of precursors on physical and biological properties of mesoporous bioactive glass

Shah, A.T. and Ain, Q. and Chaudhry, A.A. and Khan, A.F. and Iqbal, B. and Ahmad, S. and Siddiqi, S.A. and Rehman, I. (2015) A study of the effect of precursors on physical and biological properties of mesoporous bioactive glass. Journal of Materials Science, 50 (4). pp. 1794-1804. ISSN 0022-2461

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Abstract

A novel mesoporous bioactive glass (MBG) of composition 64SiO 2 –26CaO–10P 2 O 5 (mol %) was prepared by hydrothermal method using H 3 PO 4 as a precursor for P 2 O 5 . The effect of use of organic triethylphosphate (TEP) and inorganic H 3 PO 4 in MBG synthesis on glass transition temperature (T g ), crystallinity, morphology and bioactivity of MBGs was studied. Phase purity determination and structural analysis were done using powder X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy, respectively. XRD revealed that MBG prepared from H 3 PO 4 (MBG-H 3 PO 4 ) when sintered at 700 °C was partially glassy/amorphous in nature and contained a mixture of crystalline apatite, wollastonite, calcium phosphate and calcium silicate phases. Calcined MBG prepared from TEP (MBG-TEP) contained only wollastonite and calcium silicate phases. Particle size and surface area determined by BET surface area analysis showed higher surface area (310 m 2  g −1 ) for MBG-H 3 PO 4 as compared to MBG-TEP (86 m 2  g −1 ). It also had a smaller particle size (20 nm) and 70 % higher pore volume (0.88 cm 3  g −1 ) for MBG-H 3 PO 4 as compared to MBG-TEP (60 nm particle size and 0.23 cm 3  g −1 pore volume). Thermal studies showed that use of H 3 PO 4 decreases T g and increased ΔT (difference between T g and crystallization initiation temperature Tc o ). Low T g and high ΔT also enhanced bioactivity of MBGs. Bioactivity was determined by immersion in a simulated body fluid for varying time intervals for a maximum period of 14 days. It revealed enhanced bioactivity, as evident by the formation of apatite layer on the surface, for MBG-H 3 PO 4 as compared to MBG-TEP. Scanning electron microscopy and FTIR spectroscopy also supported this observation. Antibacterial studies with Escherichia Coli bacteria, MBG-H 3 PO 4 showed better antibacterial behaviour than MBG-TEP. © 2014, Springer Science+Business Media New York.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Materials Science
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2200/2210
Subjects:
ID Code:
132825
Deposited By:
Deposited On:
16 Apr 2019 09:10
Refereed?:
Yes
Published?:
Published
Last Modified:
20 May 2020 07:20