Heparin binding chitosan derivatives for production of pro-angiogenic hydrogels for promoting tissue healing

Yar, Muhammad and Shahzad, Sohail and Shahzadi, Lubna and Shahzad, Sohail Anjum and Mahmood, Nasir and Chaudhry, Aqif Anwar and Rehman, Ihtesham Ur and MacNeil, Sheila (2017) Heparin binding chitosan derivatives for production of pro-angiogenic hydrogels for promoting tissue healing. Materials Science and Engineering: C, 74. pp. 347-356. ISSN 0928-4931

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Abstract

Our aim was to develop a biocompatible hydrogel that could be soaked in heparin and placed on wound beds to improve the vasculature of poorly vascularized wound beds. In the current study, a methodology was developed for the synthesis of a new chitosan derivative (CSD-1). Hydrogels were synthesized by blending CSD-1 for either 4 or 24 h with polyvinyl alcohol (PVA). The physical/chemical interactions and the presence of specific functional groups were confirmed by Fourier transform infrared (FT-IR) spectroscopy and proton nuclear magnetic resonance (1H NMR). The porous nature of the hydrogels was confirmed by scanning electron microscopy (SEM). Thermal gravimetric analysis (TGA) showed that these hydrogels have good thermal stability which was slightly increased as the blending time was increased. Hydrogels produced with 24 h of blending supported cell attachment more and could be loaded with heparin to induce new blood vessel formation in a chick chorionic allantoic membrane assay.

Item Type:
Journal Article
Journal or Publication Title:
Materials Science and Engineering: C
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3100/3104
Subjects:
ID Code:
132733
Deposited By:
Deposited On:
12 Apr 2019 13:30
Refereed?:
Yes
Published?:
Published
Last Modified:
23 Sep 2020 05:11