Thyroxin releasing chitosan/collagen based smart hydrogels to stimulate neovascularization

Aleem, Abdur Raheem and Shahzadi, Lubna and Alvi, Farah and Khan, Ather Farooq and Chaudhry, Aqif Anwar and Rehman, Ihtesham Ur and Yar, Muhammad (2017) Thyroxin releasing chitosan/collagen based smart hydrogels to stimulate neovascularization. Materials and Design, 133. pp. 416-425. ISSN 0264-1275

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The development of new biomaterials with tailored properties is highly desired in tissue engineering field. The neovascularization is essential part of tissue regeneration which provides food and nutrients to cells. There is a real need for proangiogenic biomaterials to assist wound healing. The ideal dressing should be inexpensive and achieve rapid healing with minimal inconvenience to the patient. In this paper, new porous thyroxin containing pro-angiogenic hydrogels were generated via freeze gelation protocol. The chemical structural analysis of the synthesized hydrogels was investigated by Fourier Transform Infrared (FTIR) spectroscopy. The morphology and pore dimensions were studied by scanning electron microscopy (SEM). In swelling studies, 10 μg thyroxine loaded hydrogel (TLH-10) showed greater degree of swelling as compared to 1 μg loaded thyroxine material (TLH-1) and control. The degradation studies were tested in three different media, i.e. phosphate buffer saline (PBS), lysozyme and hydrogen peroxide and relatively higher degradation was seen in hydrogen peroxide. The synthesized materials were implanted on the chick chorioallantoic membrane to investigate their angiogenic potential. The TLH-1 hydrogel stimulated angiogenesis greater than the TLH-10; in this case blood vessels were attached and very much grown into the scaffold.

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Journal Article
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Materials and Design
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12 Apr 2019 14:30
Last Modified:
15 Sep 2023 00:53