Development of K-doped ZnO nanoparticles encapsulated crosslinked chitosan based new membranes to stimulate angiogenesis in tissue engineered skin grafts

Shahzadi, Lubna and Chaudhry, Aqif Anwar and Aleem, Abdur Raheem and Malik, Muhammad Hamza and Ijaz, Kashif and Akhtar, Hafsah and Alvi, Farah and Khan, Ather Farooq and Rehman, Ihtesham Ur and Yar, Muhammad (2018) Development of K-doped ZnO nanoparticles encapsulated crosslinked chitosan based new membranes to stimulate angiogenesis in tissue engineered skin grafts. International Journal of Biological Macromolecules, 120. pp. 721-728. ISSN 0141-8130

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Abstract

Nanoparticles are well recognized for their biological applications including tissue-regeneration due to large surface area and chemical properties. In this study, K-doped zinc oxide (ZnO) nanoparticles containing porous hydrogels were synthesized via freeze gelation. The morphology and pore dimensions were studied by scanning electron microscopy (SEM). The chemical structural analysis of the synthesized hydrogels was investigated by Fourier Transform Infrared (FTIR) spectroscopy. In swelling studies, material containing ZnO nanoparticles with 2% potassium dopant concentration CLH-K2.0) showed greater degree of swelling as compared to all other materials. The degradation studied was tested in three different degradation media, i.e. phosphate buffer saline (PBS), lysozyme and hydrogen peroxide and relatively higher degradation was seen in hydrogen peroxide. The synthesized hydrogels were implanted on the chick chorioallantoic membrane (CAM) to investigate their angiogenic potential. The CLH-K2.0 hydrogel stimulated angiogenesis greater than all other materials; blood vessels were attached and grown inside this scaffold, showing its strong angiogenic potential.

Item Type:
Journal Article
Journal or Publication Title:
International Journal of Biological Macromolecules
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300/1312
Subjects:
ID Code:
132720
Deposited By:
Deposited On:
12 Apr 2019 13:30
Refereed?:
Yes
Published?:
Published
Last Modified:
23 Sep 2020 05:11