Inflammation Response of Water-Soluble Fractions in Atmospheric Fine Particulates: A Seasonal Observation in 10 Large Chinese Cities

Ma, H. and Li, J. and Wan, C. and Liang, Y. and Zhang, X. and Dong, G. and Hu, L. and Yang, B. and Zeng, X. and Su, T. and Lu, S. and Chen, S. and Khorram, M.S. and Sheng, G. and Wang, X. and Mai, B. and Yu, Z. and Zhang, G. (2019) Inflammation Response of Water-Soluble Fractions in Atmospheric Fine Particulates: A Seasonal Observation in 10 Large Chinese Cities. Environmental Science and Technology, 53 (7). pp. 3782-3790. ISSN 0013-936X

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Abstract

Spatiotemporal trends in pro-inflammatory (interleukin (IL)-6 and IL-8) release after exposure to the water-soluble fractions of PM2.5 sampled in 10 large Chinese cities over 1 year were investigated. Chemical components (water-soluble ions, metal(loid) elements, water-soluble organic carbon (WSOC), humic-like substances (HULIS), and endotoxins) in PM2.5 samples were measured, and the molecular structure of WSOC was also analyzed by nuclear magnetic resonance. Changes in DNA methylation and gene expression of candidate genes were also evaluated to explore the potential mechanisms. PM2.5 from southern cities induced lower pro-inflammatory responses compared to those from northern cities. Seasonal differences in toxicity were noted among the cities. IL-6 was significantly correlated with HULIS (as the main fraction of WSOC with oxygenated carbohydrate structures characteristic), Pb, and endotoxin. Furthermore, DNA methylation and gene expression changes in RASSF2 and CYPIB1 were related to pro inflammatory secretion. Certain components of PM25, rather than PM2.5 mass itself, determine the pro-inflammatory release. In particular, HULIS, which originated from primary biomass burning and residual coal combustion, and secondary organic aerosols, appear to be the key component in PM2.5 to induce human health risk.

Item Type:
Journal Article
Journal or Publication Title:
Environmental Science and Technology
Additional Information:
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Environmental Science and Technology, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.est.8b05814
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1600
Subjects:
ID Code:
132559
Deposited By:
Deposited On:
24 Apr 2019 13:10
Refereed?:
Yes
Published?:
Published
Last Modified:
22 Sep 2020 04:30