Plasma neurofilament light chain:A potential prognostic biomarker of dementia in adult Down syndrome patients

Shinomoto, Makiko and Kasai, Takashi and Tatebe, Harutsugu and Kondo, Masaki and Ohmichi, Takuma and Morimoto, Masafumi and Chiyonobu, Tomohiro and Terada, Naoto and Allsop, David and Yokota, Isao and Mizuno, Toshiki and Tokuda, Takahiko (2019) Plasma neurofilament light chain:A potential prognostic biomarker of dementia in adult Down syndrome patients. PLoS ONE, 14 (4). ISSN 1932-6203

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Abstract

People with Down syndrome (DS) are at high risk of developing Alzheimer disease (AD) with aging. The diagnosis and treatment trials are hampered by a lack of reliable blood biomarkers. Plasma neurofilament light chain (NfL) is one of the established biomarkers of AD, suggesting that it may be useful as an indicator of dementia in DS patients. The aims of this study were: 1) to examine whether plasma levels of NfL in DS patients are correlated with decreased adaptive behavior scores one year after sample collection, and 2) to compare plasma levels of NfL in adults with DS and an age-matched healthy control population. In this study, plasma levels of NfL in 24 patients with DS and 24 control participants were measured by the single-molecule immunoarray (Simoa) method. We observed significantly increased plasma NfL levels in the DS compared with the control group. There was a significant correlation between age and levels of plasma NfL in both groups. This age-dependent elevation was steeper in the DS compared with the control group. Moreover, elevated plasma NfL was associated with decreased adaptive behavior scores one year later, after age-adjustment. Previously reported blood-based biomarkers available in Simoa for DS, plasma total tau and phosphorylated tau, were not significantly correlated with the annual decrement of adaptive behavior scores after age-adjustment. These results suggest that plasma NfL has the potential to serve as an objective biomarker to predict dementia in adult DS patients.

Item Type: Journal Article
Journal or Publication Title: PLoS ONE
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/2700
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 132534
Deposited By: ep_importer_pure
Deposited On: 10 Apr 2019 13:15
Refereed?: Yes
Published?: Published
Last Modified: 10 Sep 2019 00:18
URI: https://eprints.lancs.ac.uk/id/eprint/132534

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