Ulvan-chitosan polyelectrolyte complexes as matrices for enzyme induced biomimetic mineralization

Dash, Mamoni and Samal, Sangram K. and Morelli, Andrea and Bartoli, Cristina and Declercq, Heidi A. and Douglas, Timothy E.L. and Dubruel, Peter and Chiellini, Federica (2018) Ulvan-chitosan polyelectrolyte complexes as matrices for enzyme induced biomimetic mineralization. Carbohydrate Polymers, 182. pp. 254-264. ISSN 0144-8617

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Polyelectrolyte complexes (PEC) of chitosan and ulvan were fabricated to study alkaline phosphatase (ALP) mediated formation of apatitic minerals. Scaffolds of the PEC were subjected to ALP and successful mineral formation was studied using SEM, Raman and XRD techniques. Investigation of the morphology via SEM shows globular structures of the deposited minerals, which promoted cell attachment, proliferation and extracellular matrix formation. The PEC and their successful calcium phosphate based mineralization offers a greener route of scaffold fabrication towards developing resorbable materials for tissue engineering.

Item Type:
Journal Article
Journal or Publication Title:
Carbohydrate Polymers
Additional Information:
This is the author’s version of a work that was accepted for publication in Carbohydrate Polymers. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Carbohydrate Polymers, 182, 2018 DOI: 10.1016/j.carbpol.2017.11.016
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29 Mar 2019 13:40
Last Modified:
11 May 2022 06:24