An exploratory randomized controlled study of a healthy living intervention in early intervention services for psychosis:The intervention to encourage activity, improve diet, and reduce weight gain (INTERACT) study

Lovell, Karina and Wearden, Alison and Bradshaw, Tim and Tomenson, Barbara and Pedley, Rebecca and Davies, Linda M. and Husain, Nusrat and Woodham, Adrine and Escott, Diane and Swarbrick, Caroline M. and Femi-Ajao, Omolade and Warburton, Jeff and Marshall, Max (2014) An exploratory randomized controlled study of a healthy living intervention in early intervention services for psychosis:The intervention to encourage activity, improve diet, and reduce weight gain (INTERACT) study. Journal of Clinical Psychiatry, 75 (5). pp. 498-505. ISSN 0160-6689

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Abstract

Background: People with psychosis often experience weight gain, which places them at risk of cardiovascular disease, diabetes, and early death. Objective: To determine the uptake, adherence, and clinical effectiveness of a healthy living intervention designed to reduce weight gain. Method: An exploratory randomized controlled trial, comparing the intervention with treatment as usual (TAU) in 2 early intervention services for psychosis in England. DSM-IV classification was the diagnostic criteria used to assign the psychiatric diagnoses. The primary outcome was change in body mass index (BMI) from baseline to 12-month follow-up. The study was conducted between February 2009 and October 2012. Results: 105 service users, with a BMI of ≥ 25 (≥ 24 in South Asians), were randomized to intervention (n = 54) orTAU (n = 51) after stratification by recent commencement of antipsychotic medication. Ninety-three service users (89%) were followed up at 12 months. Between-group difference in change in BMI was not significant (effect size = 0.11).The effect of the intervention was larger (effect size = 0.54, not significant) in 15 intervention (28%) and 10TAU (20%) participants who were taking olanzapine or clozapine at randomization. Conclusions: The healthy living intervention did not show a significant difference in BMI reduction compared to the TAU group. © Copyright 2014 Physicians Postgraduate Press, Inc.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Clinical Psychiatry
Additional Information:
M1 - 24500028
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2738
Subjects:
ID Code:
132236
Deposited By:
Deposited On:
02 Apr 2019 08:35
Refereed?:
Yes
Published?:
Published
Last Modified:
24 Jun 2020 07:37