Relationship between childhood adversity and bipolar affective disorder:A systematic review and meta-analysis

Palmier-Claus, J.E. and Berry, K. and Bucci, S. and Mansell, W. and Varese, F. (2016) Relationship between childhood adversity and bipolar affective disorder:A systematic review and meta-analysis. British Journal of Psychiatry, 209 (6). pp. 454-459. ISSN 0007-1250

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Abstract

Background The relationship between childhood adversity and bipolar affective disorder remains unclear. Aims To understand the size and significance of this effect through a statistical synthesis of reported research. Method Search terms relating to childhood adversity and bipolar disorder were entered into Medline, EMBASE, PsycINFO and Web of Science. Eligible studies included a sample diagnosed with bipolar disorder, a comparison sample and a quantitative measure of childhood adversity. Results In 19 eligible studies childhood adversity was 2.63 times (95% CI 2.00–3.47) more likely to have occurred in bipolar disorder compared with non-clinical controls. The effect of emotional abuse was particularly robust (OR = 4.04, 95% CI 3.12–5.22), but rates of adversity were similar to those in psychiatric controls. Conclusions Childhood adversity is associated with bipolar disorder, which has implications for the treatment of this clinical group. Further prospective research could clarify temporal causality and explanatory mechanisms.

Item Type:
Journal Article
Journal or Publication Title:
British Journal of Psychiatry
Additional Information:
https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/relationship-between-childhood-adversity-and-bipolar-affective-disorder-systematic-review-and-metaanalysis/874AA2A1899F751049235F7953299350 The final, definitive version of this article has been published in the British Journal of Psychiatry, 209 (6), pp 454-459 2016, © 2016 Cambridge University Press.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700/2738
Subjects:
ID Code:
131763
Deposited By:
Deposited On:
08 Mar 2019 10:05
Refereed?:
Yes
Published?:
Published
Last Modified:
29 Sep 2020 04:50