The first identification of nesfatin-1-expressing neurons in the human bed nucleus of the stria terminalis

Pałasz, Artur and Bogus, Katarzyna and Suszka-Świtek, Aleksandra and Kaśkosz, Andrzej and Saint-Remy, Shirley and Piwowarczyk-Nowak, Aneta and Filipczyk, Łukasz and Worthington, John Joseph and Mordecka-Chamera, Kinga and Kostro, Karol and Bajor, Grzegorz and Wiaderkiewicz, Ryszard (2019) The first identification of nesfatin-1-expressing neurons in the human bed nucleus of the stria terminalis. Journal of Neural Transmission. ISSN 0300-9564

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Abstract

Neuropeptides are involved in various brain activities being able to control a wide spectrum of higher mental functions. The purpose of this concise structural investigation was to detect the possible immunoreactivity of the novel multifunctional neuropeptide nesfatin-1 within the human bed nucleus of the stria terminalis (BNST). The BNST is involved in the mechanism of fear learning, integration of stress and reward circuits, and pathogenesis of addiction. Nesfatin-1-expressing neurons were identified for the first time in several regions of the BNST using both immunohistochemical and fluorescent methods. This may implicate a potential contribution of this neuropeptide to the BNST-related mechanisms of stress/reward responses in the human brain.

Item Type: Journal Article
Journal or Publication Title: Journal of Neural Transmission
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/2800/2808
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 131486
Deposited By: ep_importer_pure
Deposited On: 19 Feb 2019 11:20
Refereed?: Yes
Published?: Published
Last Modified: 14 Sep 2019 03:08
URI: https://eprints.lancs.ac.uk/id/eprint/131486

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