Autophagy promotes visceral aging in wild-type C. elegans

Benedetto, Alexandre and Gems, David (2019) Autophagy promotes visceral aging in wild-type C. elegans. Autophagy, 15 (4). pp. 737-732. ISSN 1554-8627

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Abstract

A plethora of studies over several decades has demonstrated the importance of autophagy in aging and age-related neurodegenerative disease. The role of autophagy in damage clearance and cell survival is well established, and supports a prevailing view that increasing autophagic activity can be broadly beneficial, and could form the basis of anti-aging interventions. However, macroautophagy/autophagy also promotes some elements of senescence. For example, in C. elegans hermaphrodites it facilitates conversion of intestinal biomass into yolk, leading to sex-specific gut atrophy and senescent steatosis.

Item Type:
Journal Article
Journal or Publication Title:
Autophagy
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1300/1312
Subjects:
ID Code:
131120
Deposited By:
Deposited On:
11 Feb 2019 15:25
Refereed?:
Yes
Published?:
Published
Last Modified:
30 Sep 2020 08:36