Gibby, William Alexander Thomas and Barabash, Miraslau and Guardiani, Carlo and Luchinsky, Dmitry and Fedorenko, Olena and Roberts, Stephen Kenneth and McClintock, Peter Vaughan Elsmere (2019) Theory and experiments on multi-ion permeation and selectivity in the NaChBac ion channel. Fluctuation and Noise Letters, 18 (2): 1940007. ISSN 0219-4775
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Abstract
The highly selective permeation of ions through biological ion channels is an unsolved problem of noise and fluctuations. In this paper, we motivate and introduce a non-equilibrium and self-consistent multi-species kinetic model, with the express aims of comparing with experimental recordings of current versus voltage and concentration and extracting important permeation parameters. For self-consistency, the behavior of the model at the two-state, i.e., selective limit in linear response, must agree with recent results derived from an equilibrium statistical theory. The kinetic model provides a good fit to data, including the key result of an anomalous mole fraction effect.