Theory and experiments on multi-ion permeation and selectivity in the NaChBac ion channel

Gibby, William Alexander Thomas and Barabash, Miraslau and Guardiani, Carlo and Luchinsky, Dmitry and Fedorenko, Olena and Roberts, Stephen Kenneth and McClintock, Peter Vaughan Elsmere (2019) Theory and experiments on multi-ion permeation and selectivity in the NaChBac ion channel. Fluctuation and Noise Letters, 18 (2): 1940007. ISSN 0219-4775

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The highly selective permeation of ions through biological ion channels is an unsolved problem of noise and fluctuations. In this paper, we motivate and introduce a non-equilibrium and self-consistent multi-species kinetic model, with the express aims of comparing with experimental recordings of current versus voltage and concentration and extracting important permeation parameters. For self-consistency, the behavior of the model at the two-state, i.e., selective limit in linear response, must agree with recent results derived from an equilibrium statistical theory. The kinetic model provides a good fit to data, including the key result of an anomalous mole fraction effect.

Item Type:
Journal Article
Journal or Publication Title:
Fluctuation and Noise Letters
Uncontrolled Keywords:
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Deposited On:
08 Feb 2019 16:10
Last Modified:
07 Nov 2023 00:59