Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia

Ockleford, Colin and Adriaanse, Paulien and Berny, Philippe and Brock, Theodorus and Duquesne, Sabine and Grilli, Sandro and Hernandez-Jerez, Antonio F and Bennekou, Susanne Hougaard and Klein, Michael and Kuhl, Thomas and Laskowski, Ryszard and Machera, Kyriaki and Pelkonen, Olavi and Pieper, Silvia and Smith, Rob and Stemmer, Michael and Sundh, Ingvar and Teodorovic, Ivana and Tiktak, Aaldrik and Topping, Chris J and Wolterink, Gerrit and Angeli, Karine and Fritsche, Ellen and Leist, Marcel and Mantovani, Alberto and Menendez, Pablo and Price, Anna and Viviani, Barbara and Chiusolo, Arianna and Ruffo, Federica and Terron, Andrea (2017) Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia. EFSA Journal, 15 (3). ISSN 1831-4732

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Abstract In 2013, EFSA published a literature review on epidemiological studies linking exposure to pesticides and human health outcome. As a follow up, the EFSA Panel on Plant Protection Products and their residues (PPR Panel) was requested to investigate the plausible involvement of pesticide exposure as a risk factor for Parkinson's disease (PD) and childhood leukaemia (CHL). A systematic literature review on PD and CHL and mode of actions for pesticides was published by EFSA in 2016 and used as background documentation. The Panel used the Adverse Outcome Pathway (AOP) conceptual framework to define the biological plausibility in relation to epidemiological studies by means of identification of specific symptoms of the diseases as AO. The AOP combines multiple information and provides knowledge of biological pathways, highlights species differences and similarities, identifies research needs and supports regulatory decisions. In this context, the AOP approach could help in organising the available experimental knowledge to assess biological plausibility by describing the link between a molecular initiating event (MIE) and the AO through a series of biologically plausible and essential key events (KEs). As the AOP is chemically agnostic, tool chemical compounds were selected to empirically support the response and temporal concordance of the key event relationships (KERs). Three qualitative and one putative AOP were developed by the Panel using the results obtained. The Panel supports the use of the AOP framework to scientifically and transparently explore the biological plausibility of the association between pesticide exposure and human health outcomes, identify data gaps, define a tailored testing strategy and suggests an AOP's informed Integrated Approach for Testing and Assessment (IATA).

Item Type:
Journal Article
Journal or Publication Title:
EFSA Journal
Additional Information:
doi: 10.2903/j.efsa.2017.4691
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Deposited On:
29 Jan 2019 12:20
Last Modified:
01 Sep 2020 05:32