ILC2 orchestration of local immune function in adipose tissue:ILC2 orchestration of immune adipose function

Benezech, Cecile and Jackson-Jones, Lucy (2019) ILC2 orchestration of local immune function in adipose tissue:ILC2 orchestration of immune adipose function. Frontiers in Immunology, 10. ISSN 1664-3224

[img]
Preview
PDF (Benezech & Jackson-J V2)
Benezech_Jackson_J_V2.pdf - Accepted Version
Available under License Creative Commons Attribution.

Download (1MB)

Abstract

ILC2s were originally identified as IL-5 and IL-13 secreting ‘natural helper cells’ present within the fat associated lymphoid clusters of the mesenteries in both mouse and man. The presence of ILCs in adipose tissue has more recently expanded to include all ILC groups. Since their initial discovery, our knowledge of these cells and their role in adipose immune responses has expanded significantly. In this review we summarise the current literature on the role that ILC2s play in orchestrating adipose tissue function in both lean and obese states. We go on to address new data detailing interactions of adipose ILCs with innate like B-cells (IBC) and discuss how this interaction results in localised protection of mucosal sites during infection and inflammation via the production of innate antibodies.

Item Type: Journal Article
Journal or Publication Title: Frontiers in Immunology
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/2700/2723
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 130699
Deposited By: ep_importer_pure
Deposited On: 23 Jan 2019 09:00
Refereed?: Yes
Published?: Published
Last Modified: 15 Sep 2019 03:25
URI: https://eprints.lancs.ac.uk/id/eprint/130699

Actions (login required)

View Item View Item