Saccadic hypometria in drug-naive and drug-treated schizophrenic patients:A working memory deficit?

Hutton, S. B. and Cuthbert, I. and Crawford, T. J. and Kennard, C. and Barnes, T. R. E. and Joyce, E. M. (2001) Saccadic hypometria in drug-naive and drug-treated schizophrenic patients:A working memory deficit? Psychophysiology, 38 (1). pp. 125-132. ISSN 0048-5772

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Abstract

In certain conditions patients with schizophrenia make markedly smaller (hypometric) saccades than controls. This hypometria has been thought to reflect dopaminergic blockade as a result of antipsychotic medication. We tested this hypothesis by comparing the performance of an antipsychotic‐naïve group and an antipsychotic‐treated group of first‐episode schizophrenic patients on a predictive saccade paradigm. We explored the possibility that hypometria reflects a spatial working memory deficit by correlating performance on neuropsychological tests of mnemonic function with saccadic accuracy. Both the drug‐naïve and treated schizophrenic patients made hypometric saccades when compared with a group of matched controls. Primary saccade amplitude also correlated significantly with performance on some of the neuropsychological tests. These results are discussed in terms of the roles of cortical dopamine and working memory deficits in schizophrenic patients.

Item Type: Journal Article
Journal or Publication Title: Psychophysiology
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/2700/2737
Subjects:
Departments: Faculty of Science and Technology > Psychology
ID Code: 130396
Deposited By: ep_importer_pure
Deposited On: 11 Jan 2019 11:30
Refereed?: Yes
Published?: Published
Last Modified: 06 Jan 2020 03:24
URI: https://eprints.lancs.ac.uk/id/eprint/130396

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