Seasonal fluctuation of lung function in cystic fibrosis : A national register-based study in two northern European populations

Qvist, Tavs and Schlüter, Daniela K and Rajabzadeh, Vian and Diggle, Peter John and Pressler, Tania and Carr, Siobhan B and Taylor-Robinson, David (2019) Seasonal fluctuation of lung function in cystic fibrosis : A national register-based study in two northern European populations. Journal of Cystic Fibrosis, 18 (3). pp. 390-395. ISSN 1569-1993

[thumbnail of Seasonality_paper_revision_Clean (1)]
PDF (Seasonality_paper_revision_Clean (1))
Seasonality_paper_revision_Clean_1_.pdf - Accepted Version
Available under License Creative Commons Attribution-NonCommercial-NoDerivs.

Download (757kB)


Background Many risk factors for lung disease in cystic fibrosis (CF) display a seasonal pattern yet it is unclear whether this is reflected in seasonal fluctuations in lung function. Methods We conducted a longitudinal study using CF registries in Denmark and the UK. 485 individuals with a median of 103 FEV1 measurements per person and 7622 individuals with a median of nine FEV1 measures per person were included from Denmark and the UK respectively. We estimated the effect of seasonality on percent predicted FEV1 trajectories using mixed effects models whilst adjusting for clinically important covariates. Results We found no significant cyclical seasonal variation in lung function in either country. The maximum variation in percent predicted FEV1 around the yearly average was estimated to be 0.1 percentage points (95%CI 0 to 0.21) and 0.14 percentage points (95%CI 0 to 0.29) in Denmark and the UK, respectively. When considering possible step-like changes between the four seasons, we found that lung function was higher in spring compared to winter in the UK (0.34 percentage points, 95%CI 0.1 to 0.59) though the difference was not of clinical significance. Conclusion In both the UK and Denmark there may be small seasonal changes in lung function but this effect is not of clinical importance.

Item Type:
Journal Article
Journal or Publication Title:
Journal of Cystic Fibrosis
Additional Information:
This is the author’s version of a work that was accepted for publication in Journal of Cystic Fibrosis. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Cystic Fibrosis, 18,3, 2018 DOI: 10.1016/j.jcf.2018.10.006
Uncontrolled Keywords:
?? seasonalityseasonfluctuationpercent predicted fev1pediatrics, perinatology, and child healthpulmonary and respiratory medicine ??
ID Code:
Deposited By:
Deposited On:
12 Oct 2018 13:10
Last Modified:
17 Jul 2024 23:44