Electrically Conductive Polydopamine–Polypyrrole as High Performance Biomaterials for Cell Stimulation in Vitro and Electrical Signal Recording in Vivo

Kim, Semin and Jang, Lindy and Jang, Minsu and Lee, Sanghun and Hardy, John George and Lee, Jae (2018) Electrically Conductive Polydopamine–Polypyrrole as High Performance Biomaterials for Cell Stimulation in Vitro and Electrical Signal Recording in Vivo. ACS Applied Materials and Interfaces, 10 (39). pp. 33032-33042. ISSN 1944-8244

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Abstract

Conductive polymers (CPs) such as polypyrrole (PPY) are emerging biomaterials for use as scaffolds and bioelectrodes which interact with biological systems electrically. Still, more electrically conductive and biologically interactive CPs are required to develop high performance biomaterials and medical devices. In this study, in situ electrochemical copolymerization of polydopamine (PDA) and PPY were performed for electrode modification. Their material and biological properties were characterized using multiple techniques. The electrical properties of electrodes coated with PDA/PPY were superior to electrodes coated with PPY alone. The growth and differentiation of C2C12 myoblasts and PC12 neuronal cells on PDA/PPY was enhanced compared to PPY. Electrical stimulation of PC12 cells on PDA/PPY further promoted neuritogenesis. In vivo electromyography signal measurements demonstrated more sensitive signals from tibia muscles when using PDA/PPY-coated electrodes than bare or PPY-coated electrodes, revealing PDA/PPY to be a high-performance biomaterial with potential for various biomedical applications.

Item Type:
Journal Article
Journal or Publication Title:
ACS Applied Materials and Interfaces
Additional Information:
This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials and Interfaces, copyright © 2018 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acsami.8b11546
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2500
Subjects:
ID Code:
127742
Deposited By:
Deposited On:
18 Oct 2018 13:02
Refereed?:
Yes
Published?:
Published
Last Modified:
22 Sep 2020 04:09