Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling

Lin, Hungyen and Pei, Chunlei and Markl, Daniel and Shen, Yaochun and Elliott, James A. and Zeitler, J Axel (2018) Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling. IET Microwaves, Antennas and Propagation, 12 (11). pp. 1775-1779. ISSN 1751-8733

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Abstract

In recent years, terahertz in-line sensing has been used to monitor the film coating thickness of individual pharmaceutical tablets during the coating process. In the previous work, the in-line measurements were verified against off-line measurements of samples from the same population. Here, we report on our recent progress to further verify the validity of the terahertz in-line measurement modality using discrete element modelling for an artificial lab-scale tablet mixing process inside a tablet pan coater. By coupling discrete modelling with a ray-tracing method, it is then possible to estimate the cumulative measurements taken, which in turn can guide towards the fine-tuning of the selection criteria as part of measurement analysis. © The Institution of Engineering and Technology 2018.

Item Type:
Journal Article
Journal or Publication Title:
IET Microwaves, Antennas and Propagation
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2200/2208
Subjects:
ID Code:
126606
Deposited By:
Deposited On:
01 Aug 2018 13:08
Refereed?:
Yes
Published?:
Published
Last Modified:
05 Dec 2020 04:59