Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

Witt, S H and Streit, F and Jungkunz, M and Frank, J and Awasthi, S and Reinbold, C S and Treutlein, J and Degenhardt, F and Forstner, A J and Heilmann-Heimbach, S and Dietl, L and Schwarze, C E and Schendel, D and Strohmaier, J and Abdellaoui, A and Adolfsson, R and Air, T M and Akil, H and Alda, M and Alliey-Rodriguez, N and Andreassen, O A and Babadjanova, G and Bass, N J and Bauer, M and Baune, B T and Bellivier, F and Bergen, S and Bethell, A and Biernacka, J M and Blackwood, D H R and Boks, M P and Boomsma, D I and Børglum, A D and Borrmann-Hassenbach, M and Brennan, P and Budde, M and Buttenschøn, H N and Byrne, E M and Cervantes, P and Clarke, T-K and Craddock, N and Cruceanu, C and Curtis, D and Jones, I and Jones, L A and McIntosh, A M and Scott, L and Vincent, J B and Witt, C C and Knight, Jo (2017) Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia. Translational Psychiatry, 7 (6). ISSN 2158-3188

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Abstract

Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case-control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic overlap between BIP, major depression (MDD) and schizophrenia (SCZ) and a high comorbidity of BOR and MDD, we also analyzed the genetic overlap of BOR with SCZ and MDD. GWAS, gene-based tests and gene-set analyses were performed in 998 BOR patients and 1545 controls. Linkage disequilibrium score regression was used to detect the genetic overlap between BOR and these disorders. Single marker analysis revealed no significant association after correction for multiple testing. Gene-based analysis yielded two significant genes: DPYD (P=4.42 × 10-7) and PKP4 (P=8.67 × 10-7); and gene-set analysis yielded a significant finding for exocytosis (GO:0006887, PFDR=0.019; FDR, false discovery rate). Prior studies have implicated DPYD, PKP4 and exocytosis in BIP and SCZ. The most notable finding of the present study was the genetic overlap of BOR with BIP (rg=0.28 [P=2.99 × 10-3]), SCZ (rg=0.34 [P=4.37 × 10-5]) and MDD (rg=0.57 [P=1.04 × 10-3]). We believe our study is the first to demonstrate that BOR overlaps with BIP, MDD and SCZ on the genetic level. Whether this is confined to transdiagnostic clinical symptoms should be examined in future studies.

Item Type: Journal Article
Journal or Publication Title: Translational Psychiatry
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/2800/2803
Subjects:
Departments: Faculty of Health and Medicine > Medicine
ID Code: 126537
Deposited By: ep_importer_pure
Deposited On: 25 Jul 2018 13:34
Refereed?: Yes
Published?: Published
Last Modified: 13 Nov 2019 07:42
URI: https://eprints.lancs.ac.uk/id/eprint/126537

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