An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda

Al-Shehri, Hajri and Stanton, Michelle C and LaCourse, James E and Atuhaire, Aaron and Arinaitwe, Moses and Wamboko, Aida and Adriko, Moses and Kabatereine, Narcis B and Stothard, J Russell (2016) An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda. Transactions of The Royal Society of Tropical Medicine and Hygiene, 110 (10). pp. 597-603. ISSN 0035-9203

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Abstract

BACKGROUND: Water-borne parasitic diseases associated with poverty still blight the lives of African school children. In Uganda, intestinal schistosomiasis is still common along the shoreline of Lake Albert, despite ongoing control, and co-infection with giardiasis and malaria is poorly described. To shed light on putative interactions between diseases, a prospective cross-sectional parasitological survey was undertaken in five primary schools. METHODS: Stool samples from 254 school children, aged 5-10 years, were examined by microscopy and rapid diagnostic tests (RDTs), with additional real-time PCR assays for detection of Giardia DNA. A finger-prick blood sample was also taken from each child and tested for malaria, and haemoblobin levels measured. Assocations between diseases and anaemia were assessed. RESULTS: Intestinal schistosomiasis (46.5%), giardiasis (41.6%) and malaria (56.2%) were common, and a quarter of children were anaemic (<115 g/L). Up to 87.0% of children were excreting Giardia DNA and the prevalence of heavy infection by real-time PCR (Ct≤19) was 19.5%, being positively associated with light, moderate and heavy egg-patent schistosomiasis, as well as with anaemia. CONCLUSIONS: In this setting, an extensive burden of giardiasis was revealed with heavy intensity infections associated with egg-patent intestinal schistosomiasis and anaemia. To improve child health, greater attention on giardiasis is needed along with exploring joined-up actions across diseases that promote better water hygiene and sanitation measures.

Item Type: Journal Article
Journal or Publication Title: Transactions of The Royal Society of Tropical Medicine and Hygiene
Additional Information: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Transactions of the Royal Society of Tropical Medicine and Hygiene following peer review. The definitive publisher-authenticated version Hajri Al-Shehri, Michelle C. Stanton, James E. LaCourse, Aaron Atuhaire, Moses Arinaitwe, Aida Wamboko, Moses Adriko, Narcis B. Kabatereine, J. Russell Stothard; An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda, Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 110, Issue 10, 1 October 2016, Pages 597–603, https://doi.org/10.1093/trstmh/trw072 is available online at: https://academic.oup.com/trstmh/article/110/10/597/2548938
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/2400/2405
Subjects:
Departments: Faculty of Health and Medicine > Medicine
ID Code: 126533
Deposited By: ep_importer_pure
Deposited On: 27 Jul 2018 10:58
Refereed?: Yes
Published?: Published
Last Modified: 07 Jan 2020 06:04
URI: https://eprints.lancs.ac.uk/id/eprint/126533

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