Efect of long‑term treatment with classical neuroleptics on NPQ/ spexin, kisspeptin and POMC mRNA expression in the male rat amygdala

Palasz, Artur and Palka, Marcelina and Filipczyk, Lukasz and Castro Menezes, Itiana and Rojczyk, Ewa and Worthington, John Joseph and Piwowarczyk-Nowak, Aneta and Krzystanek, Marek and Wiaderkiewicz, Ryszard (2018) Efect of long‑term treatment with classical neuroleptics on NPQ/ spexin, kisspeptin and POMC mRNA expression in the male rat amygdala. Journal of Neural Transmission, 125 (7). pp. 1099-1105. ISSN 0300-9564

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Abstract

Neuroleptics modulate the expression level of some regulatory neuropeptides in the brain. However, if these therapeutics infuence the peptidergic circuits in the amygdala remains unclear. This study specifes the impact profle of the classical antipsychotic drugs on mRNA expression of the spexin/NPQ, kisspeptin-1 and POMC in the rat amygdala. Animals were treated with haloperidol and chlorpromazine for 28 days prior to transcript quantifcation via qPCR. Haloperidol and chlorpromazine induced a change in the expression of all neuropeptides analyzed. Both drugs led to the decrease of Kiss-1 expression, whereas in POMC and spexin/NPQ their up-regulation in the amygdala was detected. These modulating efects on may represent alternative, so far unknown mechanisms, of classical antipsychotic drugs triggering pharmacological responses

Item Type:
Journal Article
Journal or Publication Title:
Journal of Neural Transmission
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2800/2808
Subjects:
ID Code:
126496
Deposited By:
Deposited On:
23 Jul 2018 12:10
Refereed?:
Yes
Published?:
Published
Last Modified:
24 Nov 2020 06:32