Long-term treatment with olanzapine increases the number of Sox2 and doublecortin expressing cells in the adult subventricular zone

Lasut, Barbara and Palasz, Artur and Filipczyk, Lukasz and Arias-Carrión, Oscar and Rojczyk, Ewa and Savchyna, Mariia and Bogus, Katarzyna and Worthington, John Joseph and Krzystanek, Marek and Wiaderkiewicz, Ryszard (2018) Long-term treatment with olanzapine increases the number of Sox2 and doublecortin expressing cells in the adult subventricular zone. CNS & neurological disorders drug targets, 17 (6). pp. 458-463. ISSN 1996-3181

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Abstract

Continuously active neurogenic regions in the adult brain are located in the subventricular zone (SVZ) of the lateral ventricles and subgranular zone (SGZ) of the hippocampal dentate gyrus. Neurogenesis is modulated by many factors such as growth factors, neurotransmitters and hormones. Neuropsychiatric drugs, especially antidepressants, mood stabilizers and antipsychotics may also affect the origin of neuronal cells. The purpose of this study was to determine the effects of chronic olanzapine treatment on adult rat neurogenesis at the level of the SVZ. The number of neuroblasts was evaluated using immunohistochemical and fluorescent detection of sex determining region Y-box 2 (Sox-2) and doublecortin (DCX) expressing cells. The results indicate that olanzapine has proneurogenic effects in the adult rat SVZ, as the mean number of sex determining region Y-box 2 (Sox-2) and doublecortin-positive cells increased significantly, while there was a similar tendency in the subgranular zone SGZ. Collectively, these results suggest that long-term treatment with olanzapine may stimulate neurogenic stem cell formation in the SVZ which supports adult neurogenesis.

Item Type:
Journal Article
Journal or Publication Title:
CNS & neurological disorders drug targets
Additional Information:
The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1871527317666180627113544
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2700
Subjects:
ID Code:
126495
Deposited By:
Deposited On:
31 Jul 2018 09:40
Refereed?:
Yes
Published?:
Published
Last Modified:
28 Oct 2020 06:38