Engaging with Raman spectroscopy to investigate antibody aggregation

Ettah, Ilokugbe and Ashton, Lorna (2018) Engaging with Raman spectroscopy to investigate antibody aggregation. Antibodies.

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Abstract

In the last decade, a number of studies have successfully demonstrated Raman spectroscopy as an emerging analytical technique for monitoring antibody aggregation, especially in the context of drug development and formulation. Raman spectroscopy is a robust method for investigating protein conformational changes, even in highly concentrated antibody solutions. It is non-destructive, reproducible and can probe samples in an aqueous environment. In this review, we focus on the application and challenges associated with using Raman spectroscopy as a tool to study antibody aggregates.

Item Type:
Journal Article
Journal or Publication Title:
Antibodies
ID Code:
126370
Deposited By:
Deposited On:
10 Jul 2018 15:48
Refereed?:
Yes
Published?:
Published
Last Modified:
21 Mar 2020 06:19