Engaging with Raman spectroscopy to investigate antibody aggregation

Ettah, Ilokugbe and Ashton, Lorna (2018) Engaging with Raman spectroscopy to investigate antibody aggregation. Antibodies.

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In the last decade, a number of studies have successfully demonstrated Raman spectroscopy as an emerging analytical technique for monitoring antibody aggregation, especially in the context of drug development and formulation. Raman spectroscopy is a robust method for investigating protein conformational changes, even in highly concentrated antibody solutions. It is non-destructive, reproducible and can probe samples in an aqueous environment. In this review, we focus on the application and challenges associated with using Raman spectroscopy as a tool to study antibody aggregates.

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10 Jul 2018 15:48
Last Modified:
18 Sep 2023 01:24