Dual stimuli-responsive polypyrrole nanoparticles for anticancer therapy

Hathout, Rania Mohammed Hafez Mohammed and Hardy, John George and Metwally, AbdelKader and El-Ahmady, Sherweit and Metwally, Eman and Ghonim, Noha and Bayoumy, Salma and Erfan, Tarek and Ashraf, Rosaline and Fadel, Maha and El-Kholy, Abdullah (2018) Dual stimuli-responsive polypyrrole nanoparticles for anticancer therapy. Journal of Drug Delivery Science and Technology. ISSN 1773-2247

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We report the development of dual stimuli-responsive nanoparticles with potential for anticancer therapy. The nanoparticles are composed of a conjugated polymer (polypyrrole, PPY) loaded with an anticancer drug (allicin), and were characterized by a variety of physicochemical techniques. The dual stimuli-responsive nature of the PPY nanoparticles was validated in vitro: the PPY nanoparticles delivered an anticancer drug (allicin) in response to exposure to an electric field in vitro as demonstrated with UV–vis spectroscopy; and the PPY nanoparticles exhibited photothermal activity upon irradiation with near infrared light which resulted in resulted in toxicity towards HEP G2 cells in vitro. We believe that such nanoparticles have long term potential for application in cancer therapy in a variety of tissue niches (e.g. breast cancer, liver cancer, lung cancer, skin cancer).

Item Type:
Journal Article
Journal or Publication Title:
Journal of Drug Delivery Science and Technology
Additional Information:
This is the author’s version of a work that was accepted for publication in Journal of Drug Delivery Science and Technology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Drug Delivery Science and Technology, ??, ?, 2018 DOI: 10.1016/j.ddst.2018.07.002
Uncontrolled Keywords:
?? bioelectronicsorganic electronicsbiomaterialscancerdrug deliveryregenerative medicinechemical engineering (miscellaneous)chemistry(all)biomedical engineeringbiomaterialspharmaceutical sciencesdg 3 - good health and well-being ??
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Deposited On:
04 Jul 2018 07:42
Last Modified:
03 Jan 2024 00:22