Electrochemically Enhanced Drug Delivery Using Polypyrrole Films

Shah, Sayed Ashfaq Ali and Firlak, Melike and Berrow, Stuart and Halcovitch, Nathan and Baldock, Sara Jane and Yousafzai, Bakhtiar and Hathout, Rania and Hardy, John George (2018) Electrochemically Enhanced Drug Delivery Using Polypyrrole Films. Materials, 11 (7). ISSN 1996-1944

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Abstract

The delivery of drugs in a controllable fashion is a topic of intense research activity in both academia and industry because of its impact in healthcare. Implantable electronic interfaces for the body have great potential for positive economic, health, and societal impacts; however, the implantation of such interfaces results in inflammatory responses due to a mechanical mismatch between the inorganic substrate and soft tissue, and also results in the potential for microbial infection during complex surgical procedures. Here, we report the use of conducting polypyrrole (PPY)-based coatings loaded with clinically relevant drugs (either an anti-inflammatory, dexamethasone phosphate (DMP), or an antibiotic, meropenem (MER)). The films were characterized and were shown to enhance the delivery of the drugs upon the application of an electrochemical stimulus in vitro, by circa (ca.) 10–30% relative to the passive release from non-stimulated samples. Interestingly, the loading and release of the drugs was correlated with the physical descriptors of the drugs. In the long term, such materials have the potential for application to the surfaces of medical devices to diminish adverse reactions to their implantation in vivo.

Item Type:
Journal Article
Journal or Publication Title:
Materials
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2500
Subjects:
ID Code:
126222
Deposited By:
Deposited On:
02 Jul 2018 09:16
Refereed?:
Yes
Published?:
Published
Last Modified:
12 Jul 2020 07:26