Photochemical activity of membrane-localised polyketide derived marine natural products

Powell, Kimberley J. and Richens, Joanna L. and Bramble, Jonathan P. and Han, Li Chen and Sharma, Pallavi and O'Shea, Paul and Moses, John E. (2018) Photochemical activity of membrane-localised polyketide derived marine natural products. Tetrahedron, 74 (12). pp. 1191-1198. ISSN 0040-4020

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Abstract

Marine organisms rely upon complex bio-chemical systems to manage photo-induced oxidative damage as part of a sophisticated chemical defense. Using a combination of synthetic chemistry and biophysical techniques, we provide evidence to support the notion that marine derived polyene γ-pyrone metabolites of sacoglossan molluscs become localised at cell membranes where they influence the total absorption of the harmful radiation by the lipid membrane, thereby functioning as sunscreen agents. We also report two new hyperperoxide analogues of the putative polyene biosynthetic precursors that themselves are likely candidate natural products.

Item Type:
Journal Article
Journal or Publication Title:
Tetrahedron
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/3000/3002
Subjects:
ID Code:
126032
Deposited By:
Deposited On:
25 Jun 2019 12:40
Refereed?:
Yes
Published?:
Published
Last Modified:
10 Nov 2020 06:35