An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys

Cano, Jorge and Moraga, Paula and Nikolay, Birgit and Rebollo, Maria P and Okorie, Patricia N and Davies, Emmanuel and Njenga, Sammy M and Bockarie, Moses J and Brooker, Simon J (2015) An investigation of the disparity in estimates of microfilaraemia and antigenaemia in lymphatic filariasis surveys. Transactions of The Royal Society of Tropical Medicine and Hygiene, 109 (8). pp. 529-531. ISSN 0035-9203

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Abstract

BACKGROUND: The diagnosis of lymphatic filariasis (LF) is based typically on either microfilaraemia as assessed by microscopy or filarial antigenaemia using an immuno-chromatographic test. While it is known that estimates of antigenaemia are generally higher than estimates of microfilaraemia, the extent of the difference is not known. METHODS: This paper presents the results of an extensive literature search for surveys that estimated both microfilaraemia and antigenaemia in order to better understand the disparity between the two measures. RESULTS AND CONCLUSIONS: In some settings there was a very large disparity, up to 40-70%, between estimates of microfilaraemia and antigenaemia. Regression analysis was unable to identify any predictable relationship between the two measures. The implications of findings for risk mapping and surveillance of LF are discussed.

Item Type:
Journal Article
Journal or Publication Title:
Transactions of The Royal Society of Tropical Medicine and Hygiene
Additional Information:
© The Author 2015. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/2400/2405
Subjects:
ID Code:
125731
Deposited By:
Deposited On:
06 Jun 2018 12:24
Refereed?:
Yes
Published?:
Published
Last Modified:
06 May 2020 05:59