Optimal Designs for Non-Compartmental Analysis of Pharmacokinetic Studies

Barnett, Helen Yvette and Geys, Helena and Jacobs, Tom and Jaki, Thomas Friedrich (2018) Optimal Designs for Non-Compartmental Analysis of Pharmacokinetic Studies. Statistics in Biopharmaceutical Research, 10 (4). pp. 255-263. ISSN 1946-6315

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Abstract

In traditional toxicology trials, pharmacokinetics (PK) is investigated in the satellite group of animals, and the pharmacodynamics (PD) is investigated in the study group of animals. The new blood sampling method of microsampling opens up the opportunity to investigate both PK and PD in the same animals. To avoid excessive burden on the animals from the required blood sampling, sparse sampling schemes are typically utilized. Motivated by this application, this paper introduces a procedure to choose an optimal sparse sampling scheme and sampling time points using non-compartmental methods but which can be applied to further settings beyond this. We discuss how robust designs can be obtained and we apply and evaluate the approach to a range of scenarios to give an example of how it may be implemented. The results are compared to optimal designs for model based PK.

Item Type: Journal Article
Journal or Publication Title: Statistics in Biopharmaceutical Research
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/3000/3003
Subjects:
Departments: Faculty of Science and Technology > Mathematics and Statistics
ID Code: 125143
Deposited By: ep_importer_pure
Deposited On: 14 May 2018 14:20
Refereed?: Yes
Published?: Published
Last Modified: 11 Feb 2020 04:13
URI: https://eprints.lancs.ac.uk/id/eprint/125143

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