Mild cognitive decline. A position statement of the Cognitive Decline Group of the European Innovation Partnership for Active and Healthy Ageing (EIPAHA)

Apostolo, J and Holland, Carol Ann and O'Connell, Matthew and Feeney, Joanne and Tabares-Seisdedos, Rafael and Tadros, George and Campos, Elzbieta and Santos, Nadine and Robertson, Deirdre and Marcucci, Maura and Varela, Isabel and Crespo-Facorro, Benedicto and Vieta, Eduard and Navarro, Esperanza and Selva-Vera, Gabriel and Balanza-Martinez, Vicent and Cano, Antonio (2016) Mild cognitive decline. A position statement of the Cognitive Decline Group of the European Innovation Partnership for Active and Healthy Ageing (EIPAHA). Maturitas, 83. pp. 83-93.

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ABSTRACT Introduction: Mild cognitive impairment (MCI) is a term used to describe a level of decline in cognition which is seen as an intermediate stage between normal ageing and dementia, and which many consider to be a prodromal stage of neurodegeneration that may become dementia. That is, it is perceived as a high risk level of cognitive change. The increasing burden of dementia in our society, but also our increasing understanding of its risk factors and potential interventions, require diligent management of MCI in order to find strategies that produce effective prevention of dementia. Aim: To update knowledge regarding mild cognitive impairment, and to bring together and appraise evidence about the main features of clinical interest: definitions, prevalence and stability, risk factors, screening, and management and intervention. Methods: Literature review and consensus of expert opinion. Results and conclusion: MCI describes a level of impairment in which deteriorating cognitive functions still allow for reasonable independent living, including some compensatory strategies. While there is evidence for some early risk factors, there is still a need to more precisely delineate and distinguish early manifestations of frank dementia from cognitive impairment that is less likely to progress to dementia, and furthermore to develop improved prospective evidence for positive response to intervention. An important limitation derives from the scarcity of studies that take MCI as an endpoint. Strategies for effective management suffer from the same limitation, since most studies have focused on dementia. Behavioural changes may represent the most cost-effective approach. Key words: cognition; mild cognitive decline; position statement; cognitive frailty.

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This is the author’s version of a work that was accepted for publication in Maturitas. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Maturitas, 83, 2016 DOI: 10.1016/j.maturitas.2015.10.008
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?? cognitionmild cognitive declineposition statementcognitive frailtybiochemistry, genetics and molecular biology(all)obstetrics and gynaecology ??
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11 May 2018 11:02
Last Modified:
31 Dec 2023 00:56