Jenkins, Stephen J and Ruckerl, Dominik and Cook, Peter C and Jones, Lucy H and Finkelman, Fred D and van Rooijen, Nico and MacDonald, Andrew S and Allen, Judith E (2011) Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science, 332 (6035). pp. 1284-1288. ISSN 0036-8075
Full text not available from this repository.Abstract
A defining feature of inflammation is the accumulation of innate immune cells in the tissue that are thought to be recruited from the blood. We reveal that a distinct process exists in which tissue macrophages undergo rapid in situ proliferation in order to increase population density. This inflammatory mechanism occurred during T helper 2 (T(H)2)-related pathologies under the control of the archetypal T(H)2 cytokine interleukin-4 (IL-4) and was a fundamental component of T(H)2 inflammation because exogenous IL-4 was sufficient to drive accumulation of tissue macrophages through self-renewal. Thus, expansion of innate cells necessary for pathogen control or wound repair can occur without recruitment of potentially tissue-destructive inflammatory cells.