Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation

Jenkins, Stephen J and Ruckerl, Dominik and Cook, Peter C and Jones, Lucy H and Finkelman, Fred D and van Rooijen, Nico and MacDonald, Andrew S and Allen, Judith E (2011) Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science, 332 (6035). pp. 1284-1288. ISSN 0036-8075

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Abstract

A defining feature of inflammation is the accumulation of innate immune cells in the tissue that are thought to be recruited from the blood. We reveal that a distinct process exists in which tissue macrophages undergo rapid in situ proliferation in order to increase population density. This inflammatory mechanism occurred during T helper 2 (T(H)2)-related pathologies under the control of the archetypal T(H)2 cytokine interleukin-4 (IL-4) and was a fundamental component of T(H)2 inflammation because exogenous IL-4 was sufficient to drive accumulation of tissue macrophages through self-renewal. Thus, expansion of innate cells necessary for pathogen control or wound repair can occur without recruitment of potentially tissue-destructive inflammatory cells.

Item Type:
Journal Article
Journal or Publication Title:
Science
Uncontrolled Keywords:
/dk/atira/pure/subjectarea/asjc/1000
Subjects:
ID Code:
124930
Deposited By:
Deposited On:
27 Apr 2018 13:22
Refereed?:
Yes
Published?:
Published
Last Modified:
24 Oct 2020 05:37