Correlation between bacterial G+C content, genome size and the G+C content of associated plasmids and bacteriophages

Almpanis, Apostolos and Swain, Martin and Gatherer, Derek and McEwan, Neil (2018) Correlation between bacterial G+C content, genome size and the G+C content of associated plasmids and bacteriophages. Microbial Genomics, 2018 (4). ISSN 2057-5858

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Abstract

Based on complete bacterial genome sequence data, we demonstrate a correlation between bacterial chromosome length and the G+C content of the genome, with longer genomes having higher G+C contents. The correlation value decreases at shorter genome sizes, where there is a wider spread of G+C values. However, although significant (P<0.001), the correlation value (Pearson R=0.58) suggests that other factors also have a significant influence. A similar pattern was seen for plasmids; longer plasmids had higher G+C values, although the large number of shorter plasmids had a wide spread of G+C values. There was also a significant (P<0.0001) correlation between the G+C content of plasmids and the G+C content of their bacterial host. Conversely, the G+C content of bacteriophages tended to reduce with larger genome sizes, and although there was a correlation between host genome G+C content and that of the bacteriophage, it was not as strong as that seen between plasmids and their hosts.

Item Type:
Journal Article
Journal or Publication Title:
Microbial Genomics
Subjects:
ID Code:
124844
Deposited By:
Deposited On:
23 Apr 2018 14:58
Refereed?:
Yes
Published?:
Published
Last Modified:
20 Sep 2020 04:46